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Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Fluoxetine affects certain chemical messengers (neurotransmitters) that communicate between brain cells and helps people with depression, panic, anxiety, or obsessive-compulsive symptoms.

Prozac is used to treat major depressive disorder, bulimia nervosa (an eating disorder), obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder (PMDD).

Prozac is sometimes used together with another medication called olanzapine (Zyprexa) wich we also have in our store to treat manic depression caused by bipolar disorder. This combination is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms.

Before taking Prozac

You should not use Prozac if you are allergic to fluoxetine, if you also take pimozide or thioridazine.

Do not use Prozac if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. You must wait at least 14 days after stopping an MAO inhibitor before you take fluoxetine. You must wait 5 weeks after stopping fluoxetine before you can take thioridazine or an MAOI.

Prozac Warnings!

You should not use Prozac if you also take pimozide or thioridazine, or if you are being treated with methylene blue injection.

Do not use Prozac if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, rasagiline, selegiline, phenelzine, or transcypromine). Do not use fluoxetine with thioridazine, linezolid, pimozide, or methylene blue injection. You must wait at least 14 days after stopping an MAO inhibitor before you take Prozac. You must wait 5 weeks after stopping Prozac before you can take thioridazine or an MAOI.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms.

Prozac could impair judgment, thinking, or motor skills. Use caution when operating machinery.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

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Prozac is it better then therapy ?


There has been a popular notion that drug treatment of behavioral health problems is less expensive than psychotherapy by behavioral health specialists. But in 1991, I conducted an (unpublished) study to test this idea in a 5,000-member health plan—and found that psychotherapy actually saved money compared with drug treatment.

My company at the time, Preferred Mental Health Management (PMHM), provided the cost and utilization numbers of behavioral treatment, while a company called National Prescription Administrators provided the psychiatric drug treatment costs.

At PMHM, our philosophy was unique in the industry. Those who wanted mental health treatment called PMHM and had a ten- to twenty-minute telephone assessment with a senior level psychologist, who then referred the caller to a BH specialist in the caller’s community.

PMHM’s behavioral treatment philosophy was to focus on and help resolve the patient’s current life factor problems, which were giving rise to the patient’s distressing symptoms. PMHM never recommended medication for callers complaining of depression or anxiety.

The following are some of the major findings from the study:

  1. Psychiatric drug treatment was found to cost $4.21 per member per month, which included the physician charges for prescribing and monitoring the drug treatment.
  2. Psychotherapy was found to cost only $0.85 per member per month—80% less than psychiatric drug treatment costs!
  3. For psychiatric drug therapy, the average cost per treated patient was $315.72.
  4. For psychotherapy, the average cost per treated patient was $204.56—35% less than the cost for the average drug treated patient.
  5. Eighty percent of the psychiatric drugs in the plan were prescribed by non-psychiatric physicians.
  6. Eighty-one percent of the plan members receiving psychiatric drugs were on antidepressants, which amounted to 62% of the total behavioral drug costs.
  7. In the year following the collection of this data there was a 25% increase in the plan’s psychiatric drug expenditures.
  8. There seems to have been a polypharmacy or “shotgun” approach in which prescribers may have been chasing symptom and or side effects. Thirty-three percent of those receiving psychiatric drugs had prescriptions from two or more psychiatric drug classes, which of course exposes these patients to increasing side effects.
  9. Patients on antianxiety drugs were prescribed, on average, 1.4 antianxiety drugs. This statistic suggests that the primary drug may not have been effective, so a second (and in some cases a third or fourth) drug was prescribed.
  10. The average number of psychiatric prescriptions per patient was 2.06.
  11. Thirty-eight children were on psychiatric drugs that are not approved by the FDA for use with children.

Those on Multiple Classes of Drugs

The data on antidepressant prescriptions may indicate that there may be a search by the physician to find the right drug for the patient’s depression and anxiety:

For depression, 101 patients (63%) were taking one antidepressant, 41 (25%) were taking two different antidepressants, 14 patients had been prescribed three different antidepressants, two were on four antidepressants and two were on five antidepressants!

Psychiatry and the pharmaceutical industry have been promoting the belief that depression is a brain disease affecting one or more neurotransmitters in the brain, so I suspect that the prescribers might have been looking for the right drug to reach the right source of this patient’s depression.

I suspect that when one observes multiple prescriptions (both within and between drug classes, as in the above) it is likely that the patient is not improving, causing the prescriber to search for another drug to help the patient.

I remember a psychiatrist saying, when his patient had not responded to multiple antidepressant drugs, that his patient’s only hope was for the drug industry to come up with a new antidepressant to successfully treat his patient’s particular depression!

However, when multiple drugs fail to treat depression, is it possible that drugs may not be an effective treatment for depression? Fifty years ago, psychiatrists used to do psychotherapy, but now in psychiatry, drug treatment is seen as the only possibility!

I had a consulting board-certified psychiatrist review 16 of what I thought were the worst examples of inappropriate psychiatric drug prescribing. Here are four of the most egregious examples:

  • Patient A was prescribed a stimulant, two antidepressants, and a third, sedating antidepressant.
  • Patient B was prescribed three mood stabilizers, an anticonvulsant, four benzodiazepines, two antipsychotics, three antidepressants, and one sedating antidepressant.
  • Patient C was prescribed a short-acting benzodiazepine and four different antidepressants of different strengths, one with sedative qualities.
  • Patient D was prescribed three mood stabilizers, four benzodiazepines, an anticonvulsant, an antipsychotic, and two antidepressants.

One can only imagine the adverse side effect profile of these patients on multiple psychiatric drugs, and with such egregious examples of polypharmacy, one cannot hope for a good treatment outcome.

I have no reason to believe that the inappropriate and egregious prescribing patterns found in this study are unique compared to other health plans. In the intervening years since this study, it is likely that the psychiatric drug prescribing has become worse rather than better.

What can we learn from this case study?

Prior to the appearance of Prozac in 1987, primary care and other non-psychiatric physicians rarely tried to diagnose their patients with mental health problems. Instead, medical professionals referred these patients to psychiatrists and, to a lesser extent, to psychologists. Prozac was hailed in many quarters as a breakthrough mental health drug, a wonder drug that cured depression and even made emotionally normal people better that normal!

Beginning in the 1950s, psychiatry, the pharmaceutical industry, and the mental health associations began a movement that might be called the medicalization of mental health problems, a movement that was said to reduce the stigma of those with mental health problems. The message was that mental health problems were just like any other medical problems.

This “theory” or “little white lie” would enable more patients with these problems to come forward for treatment. In the late 1960s, when this “theory” was becoming rampant, my colleagues and I knew this message had absolutely no validity. But the psychiatrists argued for the message (read: bold-faced lie) because of the anticipated good result! I, for one, had too much of a belief in science and truth to get on the bandwagon of this movement.

What are a few of the unintended consequences of this “little white lie”?

1. Primary care and other non-psychiatric physicians have become the largest “behavioral health” profession in the U.S. and prescribe 80% of all psychiatric drugs. General physicians have dominated the field of mental health treatment based only on a six-week rotation in psychiatry during their clinical internship. This movement was fueled by psychiatry’s and the pharmaceutical industry’s propaganda that depression and the other mental disorders are brain diseases.

Because they were considered brain diseases, the cure would come from pharmaceuticals or other biophysical treatments to address various putative neurotransmitter-related causes, such as serotonin and dopamine, among others. This message appealed very much to general physicians who were trained in the biophysical sciences.

2. General physicians were ripe to take on this message as their very own, which is apparent in the psychiatric drug prescribing patterns found in the case study under discussion. Many of these prescribing patterns are atrocious and reveal a search for the right drug to effectively treat a mythical brain disease that will cure the patient, a search fueled by the fact that the patient is not improving on the primary drug!

I have news for those who have bought into the brain disease notion of the origin of mental illness. Despite many claimed drug and other biophysical “breakthroughs” in treating the mental disorders to alter brain chemistry, why do the incidences of mental disorders and suicides continue to rise? The path that psychiatry has chosen does not seem to be working. Might it be time to once again broaden our understanding of the origin of the mental disorders?

3. In the 1950s, and even for some time afterward, psychiatric residency programs saw mental disorders as arising both from biophysical and psychosocial antecedents and prepared residents for comprehensive treatment, namely drugs when appropriate and Since then, though, the psychiatrist believers in the biophysical origins of the mental disorders have become ascendant. They now dominate the profession as a whole and provide the principal training of the next generation of psychiatrists.

4. This “scientific” organic view of the mental disorders has taken hold in almost every section of U.S. healthcare because the medical profession controls and shapes U.S. healthcare as we know it. The medical profession dominates and puts its mark on the health insurance industry as a whole, the current Managed Care Organizations, the FDA approval process, and even the health plans of private and government funded health programs.

An invitation to employer sponsored health plans to review their mental health plan for both quality and cost

I invite employer-sponsored health plans to have their pharmacy management firm replicate and expand the above study to review the quality and cost of the mental health treatment in the plan. PMHM’s system of arranging and managing the employer’s care was unique, and it only contracted with the traditional behavioral health professionals, psychologists, clinical social workers, and psychiatrists who conducted CBT.

Current behavioral health plans, unlike PMHM’ system, do not have psychologists triage those calling for mental health services, and current behavioral health plans authorize payment to several groups of professionals providing services, several with only one or two years of graduate training.

In such a new study, it would be useful to see a breakdown of prescribing by psychiatrists, as well as prescribing by non-psychiatric physicians, physician assistants, and nurse practitioners.  I cannot vouch for the quality of the services in any current plan being studied, but, for comparison purposes, the utilization and cost data of the behavioral treatment side of the plan should be included.

The study I conducted was confined to only data on psychiatric drug utilization and costs, but since then there are new costs in addition to drugs and psychotherapy—namely six or more FDA-cleared biomechanical treatments that zap the brain to address those patients whose depression does not respond to psychiatric medications. In my recent book, What’s Wrong With Much of U.S. Healthcare and How to Fix It, I have reviewed several of these biomechanical treatments, whose results I find are less than impressive.

When the pharmacy management firm has gathered the costs for both psychiatric drug prescribing and psychotherapy for a one or two year period, I would suggest retaining a psychologist and a psychiatrist (the latter an expert in psychiatric drug treatment) to review the data and to write a report and their recommendations for any changes these professionals would make to reduce and eliminate any inappropriate prescribing of these drugs, which would be a very good beginning to improve the quality and cost of providing mental health services.

Such a behavioral drug- and biomechanical-treatment study would be very enlightening, and would likely show that the present system of non-psychiatric physician responsibility for the diagnosis and treatment of the mental disorders leaves much to be desired and a new and improved system must be created.